The Impact of Curcumin on Embryonic Development: Insights From a Systematic Literature Review

Curcumin, a polyphenol compound extracted from turmeric (Curcuma longa), has been widely known for its anti-inflammatory, antioxidant, and therapeutic properties. This study aims to investigate the impact of curcumin on embryonic development, which is an important aspect of developmental biology and reproductive health. This study uses a type of literature review. The researcher used the Science Direct database, and the PubMed and Scopus data taken. This study took the source from articles published from 2015 to 2024. Search the database by entering the keywords "Curcumin" and "Embryogenesis". The criteria to be used as samples based on the PICOS criteria are as follows: Population: Embryogenesis, Human, Female, Rat, Mice, Fish. Outcome: Improved embryonic development, protection of cells from oxidation and inflammation. Four selected articles that have met the inclusion criteria. Findings suggest that curcumin at low doses (1-5 μM) can increase cell proliferation and support healthy embryo development. However, at high doses (more than 10 μM), curcumin actually causes an increased incidence of malformations and developmental disorders, which are characterized by changes in morphology and decreased embryonic viability. Histological analysis showed tissue damage in embryos exposed to high doses of curcumin. These results suggest that curcumin has a biphasic effect on embryonic development, where proper dosage can provide benefits, while overdose can be detrimental. This study highlights the importance of a deeper understanding of the dosage and timing of curcumin administration in the context of therapy and supplementation, especially in pregnant women. This study provides new insights into the impact of curcumin on embryonic development, emphasizing the need for further research to explore the therapeutic potential and risks associated with curcumin use in the context of reproductive health