Exploring the Role of MicroRNAs and Associated Proteins in Multiple Sclerosis

Introduction: Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS).The diagnosis and follow-up of MS progression are challenging because of its complex pathogenesis and the lack of specific biomarkers.This study aims to introduce related microRNAs (miRNAs) and associated proteins with MS.Methods: MS-related miRNA data of 4 peripheral blood profiles from relapsing-remitting MS patients and 8 healthy controls were extracted from the GEO database.Their related proteins were analyzed using bioinformatics methods, such as protein-protein interaction (PPI) network and action map.Results: Eighteen differential microRNA were detected, discriminating the patient samples from controls.Then, 31 related proteins were identified and assessed via PPI network analysis and action map evaluation. Conclusion:In conclusion, a protein panel of NCL, NOP58, SNRNP70, U2AF2, YBX1, PRPF8, BOP1, and PIK3K as the crucial individuals associated with MS are suggested for further investigation.