Clostridioides difficile evolution in a tertiary German hospital through a retrospective genomic characterization
This study highlights the dynamic strain evolution of C. difficile, reflecting national trends in strain evolution. The findings emphasize the strong correlation between epsilometer MIC values and molecular resistance markers. This observation reinforces the integration of genetic surveillance with antibiotic stewardship in the clinical routine to effectively mitigate CDI recurrence. Further research is needed to better understand the complex interactions between antibiotic exposure and strain evolution in hospital environments.
Authors
- Tilman E. Klassert (ORCID: https://orcid.org/0000-0002-4502-5450)
- Fabián Lorenzo-Díaz (ORCID: https://orcid.org/0000-0002-3398-198X)
- Hortense Slevogt (ORCID: https://orcid.org/0000-0001-7104-9547)
- Cristina Zubiría-Barrera
- Mario A. González Carracedo (ORCID: https://orcid.org/0000-0003-1386-0571)
- Mariano Hernández (ORCID: https://orcid.org/0000-0003-1219-0246)
- Thomas Grünewald
- Amelya Keles-Slevogt
Institutions
- Universidad de La Laguna (ES)
- German Center for Neurodegenerative Diseases (DE)
- Medizinische Hochschule Hannover (DE)
- Helmholtz Centre for Infection Research (DE)
- Instituto Canario de Investigaciones Agrarias (ES)
- Klinikum Chemnitz (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Infection
- Published
- 2025-06-08
- DOI
- https://doi.org/10.1007/s15010-025-02576-y
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad de La Laguna
- Deutsche Forschungsgemeinschaft