Cerebral Venous Sinus Thrombosis During Raloxifene Therapy: A Case Report

A 79-year-old woman taking raloxifene for osteoporosis was admitted to our hospital with right-sided hemiplegia and seizures. Computed tomography (CT) of the head revealed a subcortical hemorrhage in the left frontal to parietal lobes. CT venography (CTV) showed a disruption of the superior sagittal sinus, leading to a diagnosis of cerebral venous sinus thrombosis (CVST). In the absence of other thrombogenic factors, raloxifene was considered a potential contributing factor. She received continuous intravenous heparin followed by warfarin, without clinical deterioration, and was later transferred to a rehabilitation hospital. Although venous thrombosis is a recognized adverse effect of raloxifene, CVST remains an uncommon manifestation. We therefore present this case to highlight the potential association.