Loss of YTHDF1 suppresses the progression of malignant rhabdoid tumor of the kidney by regulating Glutathione S-transferase Mu 2 (GSTM2)
In summary, our findings provide new insights into the molecular mechanisms driving MRTK progression, highlighting YTHDF1 and GSTM2 as potential therapeutic targets for this aggressive pediatric renal tumor.
Authors
- Qian-Wen Xiong
- Jinhu Wang (ORCID: https://orcid.org/0000-0002-7749-2475)
- Gensheng Zhang (ORCID: https://orcid.org/0000-0002-8157-6460)
- Xian Shen (ORCID: https://orcid.org/0000-0003-3331-1676)
- Shuang-Ai Liu
- Wan‐Xin Peng (ORCID: https://orcid.org/0000-0002-2551-8899)
- Qian Liu (ORCID: https://orcid.org/0000-0003-2067-8444)
- Yuntao Liu (ORCID: https://orcid.org/0000-0002-4334-0406)
- Manli Zhao (ORCID: https://orcid.org/0009-0005-9218-5309)
- Min He (ORCID: https://orcid.org/0000-0003-0178-097X)
Institutions
- Zhejiang Chinese Medical University (CN)
- Children's Hospital of Zhejiang University (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cell Biology and Toxicology
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1007/s10565-025-10049-z
- Citations
- 1
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province