LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer
We identify a novel regulatory axis in which PVT1 promotes cuproptosis by epigenetically activating FDX1 in colorectal cancer. Targeting the PVT1-FDX1 axis may offer an effective anticancer strategy, particularly given the widespread overexpression of PVT1 and its role in therapy resistance.
Authors
- Yingbin Hu (ORCID: https://orcid.org/0000-0003-3645-7339)
- Meichen Zhang
- Zhuoran Sun
- Lingling Zhang
- Yingjie Zhang (ORCID: https://orcid.org/0009-0000-7284-2424)
- Xiang Li (ORCID: https://orcid.org/0000-0003-2557-8899)
- Mengmeng Chen (ORCID: https://orcid.org/0000-0003-3768-9713)
- Jingjing Jiang (ORCID: https://orcid.org/0000-0002-5646-6040)
- Jinyan Ma
- Jueting Cai
Institutions
- Central South University (CN)
- Hunan University (CN)
- Changsha University (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1016/j.redox.2025.103722
- Citations
- 9
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 8.43
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province