Plasma biomarkers for early detection of alzheimer’s disease: a cross-sectional study in a Japanese cohort
Plasma biomarkers, Aβ42/40 and p-tau217, and particularly their ratio (p-tau217/Aβ42), show strong potential as Aβ PET alternatives for AD diagnosis. HISCL-based plasma Aβ42/40 detects Aβ accumulation earlier than Aβ PET visual reading threshold, underscoring its utility as an early diagnostic marker.
Authors
- Ryo Shikimoto (ORCID: https://orcid.org/0000-0002-7410-3067)
- Daisuke Ito (ORCID: https://orcid.org/0000-0001-9977-3502)
- Masahito Kubota
- Natsumi Suzuki
- Yoshiaki Sato (ORCID: https://orcid.org/0000-0003-3375-5189)
- Shin Kurose (ORCID: https://orcid.org/0000-0001-8355-4946)
- Toshiki Tezuka (ORCID: https://orcid.org/0000-0001-9380-6756)
- Kenji Tai
- Sho Shimohama (ORCID: https://orcid.org/0000-0003-0710-6740)
- Masaru Mimura (ORCID: https://orcid.org/0000-0002-3874-5273)
- Jin Nakahara (ORCID: https://orcid.org/0000-0002-5858-0998)
- Ayaka Morimoto
- Hajime Tabuchi (ORCID: https://orcid.org/0000-0002-2321-711X)
- Hirofumi Aoyagi
- Junro Kuromitsu
- Yu Mimura (ORCID: https://orcid.org/0000-0003-0538-6785)
- Shogyoku Bun (ORCID: https://orcid.org/0000-0002-0815-1431)
- Yuki Momota
- Yu Iwabuchi (ORCID: https://orcid.org/0000-0002-9259-6651)
- Keisuke Takahata (ORCID: https://orcid.org/0009-0009-0897-8963)
- Yuka Hoshino
- Takayuki Hoshino
- Yasuharu Yamamoto
- Azusa Oosumi
Institutions
- Keio University (JP)
- National Institutes for Quantum Science and Technology (JP)
- Eisai (Japan) (JP)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1186/s13195-025-01778-8
- Citations
- 11
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 16.70
Funders
- Japan Agency for Medical Research and Development
- Keio University