NLRP3 activation promotes cGAS/STING signaling and antitumor immunity by colorectal cancer cells
Activation of NLRP3 specifically in CRC cells could be a promising strategy to boost antitumor immunity in otherwise immunotherapy resistant CRCs.
Authors
- Courtney Mowat (ORCID: https://orcid.org/0000-0001-7967-729X)
- Kristi Baker (ORCID: https://orcid.org/0000-0002-2993-3889)
- Daniel Schiller (ORCID: https://orcid.org/0000-0001-8036-504X)
Institutions
- University of Alberta (CA)
- Royal Alexandra Hospital (CA)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1007/s00262-025-04088-y
- Citations
- 6
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- University of Alberta
- University Hospital Foundation
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada