Silencing of STX4 inhibits the proliferation, migration and invasion of ovarian cancer cells via EMT/MMP2/ CCND1 signaling pathway
We demonstrated for the first time that STX4, an important regulator of OC progression, was associated with the growth and metastasis of OC cells through correlations with EMT, MMP2, and CCND1, suggesting its potential as a new therapeutic target for OC.
Authors
- Dachuan Zhang (ORCID: https://orcid.org/0000-0002-1746-275X)
- Linlin Chen (ORCID: https://orcid.org/0000-0002-7237-5915)
- Wenfeng Ye (ORCID: https://orcid.org/0000-0001-9694-8530)
- Chunyan Xue (ORCID: https://orcid.org/0000-0002-0987-6696)
- Xiangnan Chen (ORCID: https://orcid.org/0000-0002-4306-3218)
Institutions
- Soochow University (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1186/s13048-025-01705-3
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Shanghai Pudong New Area Health Commission