Bioinformatics‐Based Comparative Analysis of the Human Retina Proteome
Our results show that intrinsic disorder, LLPS, and mutational tendencies are not evenly distributed among retinal proteomes. Our study demonstrates a link between intrinsic disorder, LLPS potential, and pathogenic vulnerability among retinal proteins, underscoring the unique structural and functional landscape of retinal proteomes. Proteins with higher specificity to the retina exhibit greater disorder and phase separation potential, highlighting their potential role in dynamic cellular processes that support retinal function. Conversely, proteins widely distributed across multiple tissues tend to be more ordered, suggesting a need for structural stability in their broader functional roles.
Authors
- Michael Antonietti (ORCID: https://orcid.org/0000-0001-5526-1396)
- Mak B. Djulbegovic (ORCID: https://orcid.org/0000-0002-4149-7450)
- Nicolas A. Yannuzzi (ORCID: https://orcid.org/0009-0004-0035-7373)
- Colin Kim (ORCID: https://orcid.org/0000-0003-3729-413X)
- Carol L. Karp (ORCID: https://orcid.org/0000-0002-6452-7181)
- Vladimir Nikolaevich Uversky (ORCID: https://orcid.org/0000-0002-4037-5857)
- David J. Taylor Gonzalez (ORCID: https://orcid.org/0009-0001-2089-6153)
- Nedym Hadzijahic
- David Broytman
Institutions
- University of Miami (US)
- Thomas Jefferson University (US)
- University of South Florida (US)
- Cooper Medical School of Rowan University (US)
- Miami Dermatology and Laser Institute (US)
- USF Health Byrd Alzheimer's Institute (US)
- Wills Eye Hospital (US)
Publication Details
- Journal
- PROTEOMICS - CLINICAL APPLICATIONS
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1002/prca.70012
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health