Nuclear cholesterol regulates nuclear size and DNA damage responses in cancer stem cells

Stem-like GBM cells display reduced nuclear size, driven by nuclear cholesterol synthesis to regulate radiation responses, revealing a novel therapeutic paradigm.

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Publication Details

Journal
Neuro-Oncology
Published
2025-06-07
DOI
https://doi.org/10.1093/neuonc/noaf110
Citations
2
Primary Topic
Nuclear Structure and Function
Type
article
Field-Weighted Citation Impact
1.61
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article

Nuclear cholesterol regulates nuclear size and DNA damage responses in cancer stem cells

Suchet Taori, Sisi Lai, Frank P. Vendetti, Qiulian Wu et al.
2 citations
Neuro-Oncology
Nuclear Structure and Function
1.61
article

Nuclear cholesterol regulates nuclear size and DNA damage responses in cancer stem cells

Suchet Taori, Sisi Lai, Frank P. Vendetti, Qiulian Wu, Huairui Yuan, Xujia Wu, Hailong Mi, Cuiqing Zhong, Marlies Meisel, Christopher J. Bakkenist, Pascal Olivier Zinn, Tengfei Huang, Wei-Chi Wu, Fanen Yuan, Shira Yomtoubian, Daqi Li, Rui Wang, Huan Li, Donghai Wang, Po Zhang, Ahmed Habib, Shruti Bhargava, Farrukh Hammed
article en
2 citations

Abstract

Stem-like GBM cells display reduced nuclear size, driven by nuclear cholesterol synthesis to regulate radiation responses, revealing a novel therapeutic paradigm.

Neuro-OncologyVol. 27(10)
University of North Carolina at Chapel Hill (US), Salk Institute for Biological Studies (US), University of Pittsburgh (US), University of California San Diego (US), Cleveland Clinic Lerner College of Medicine (US), Sanford Consortium for Regenerative Medicine (US), UPMC Hillman Cancer Center (US), Spectral Labs (United States) (US), Altos Labs, UNC Lineberger Comprehensive Cancer Center
Good health and well-being
Openalex Percentile: Top 17%
Nuclear Structure and Function
1.61
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