Nuclear cholesterol regulates nuclear size and DNA damage responses in cancer stem cells
Stem-like GBM cells display reduced nuclear size, driven by nuclear cholesterol synthesis to regulate radiation responses, revealing a novel therapeutic paradigm.
Authors
- Suchet Taori (ORCID: https://orcid.org/0000-0002-4015-2880)
- Sisi Lai
- Frank P. Vendetti
- Qiulian Wu (ORCID: https://orcid.org/0000-0002-7774-9576)
- Huairui Yuan
- Xujia Wu (ORCID: https://orcid.org/0000-0002-6904-0778)
- Hailong Mi
- Cuiqing Zhong
- Marlies Meisel (ORCID: https://orcid.org/0000-0001-5156-8067)
- Christopher J. Bakkenist (ORCID: https://orcid.org/0000-0001-9672-0886)
- Pascal Olivier Zinn (ORCID: https://orcid.org/0000-0003-0091-5887)
- Tengfei Huang (ORCID: https://orcid.org/0000-0001-9795-5636)
- Wei-Chi Wu (ORCID: https://orcid.org/0000-0002-9457-5336)
- Fanen Yuan (ORCID: https://orcid.org/0000-0001-9484-5183)
- Shira Yomtoubian (ORCID: https://orcid.org/0000-0001-6856-5196)
- Daqi Li
- Rui Wang (ORCID: https://orcid.org/0000-0003-2553-620X)
- Huan Li (ORCID: https://orcid.org/0000-0001-9415-493X)
- Donghai Wang (ORCID: https://orcid.org/0000-0001-5048-5040)
- Po Zhang (ORCID: https://orcid.org/0000-0001-7847-9478)
- Ahmed Habib (ORCID: https://orcid.org/0000-0003-4908-6987)
- Shruti Bhargava
- Farrukh Hammed
Institutions
- University of North Carolina at Chapel Hill (US)
- Salk Institute for Biological Studies (US)
- University of Pittsburgh (US)
- University of California San Diego (US)
- Cleveland Clinic Lerner College of Medicine (US)
- Sanford Consortium for Regenerative Medicine (US)
- UPMC Hillman Cancer Center (US)
- Spectral Labs (United States) (US)
- Altos Labs
- UNC Lineberger Comprehensive Cancer Center
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1093/neuonc/noaf110
- Citations
- 2
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 1.61