Hepatic effects of Traumatic Brain Injury using Wistar Rats

Over the years, studies have shown that head injuries can lead to various traumatic effects on the brain. However, these injuries not only impact the brain but also affect the liver. This study examined the histopathological effects of traumatic brain injury (TBI) on the liver. Fifty Wistar rats, weighing between 150g and 250g, were divided into five groups (A–E). Group A served as the negative control, with no trauma induced. Group B received a 50g weight impact on the head, Group C was subjected to a 100g weight, Group D to a 150g weight, and Group E to a 200g weight. The injured animals were sacrificed at intervals of 5 hours, 24 hours, 7 days, and 24 days post-trauma. Their tissues were processed using paraffin embedding and Hematoxylin-Eosin staining. Histological analysis of the control group revealed normal tissue morphology. In contrast, the traumatized groups exhibited pathological changes such as edema, necrosis, apoptosis, gliosis, inflammation, cellular infiltration, and hemorrhage. These findings suggest that TBI indirectly exerts toxic effects on the liver, with the extent of damage correlating to the severity of the trauma. Keywords: hepatic, traumatic brain injury, peripheral abnormalities, and inflammation