Lipid metabolism and inflammation as key drivers in preterm birth: A comprehensive analysis

This Mendelian randomization study identifies dysregulated lipid metabolism and inflammatory pathways influencing preterm birth. It identifies dysregulated lipid metabolism and inflammatory pathways influencing preterm birth. ADA is a significant protective factor against preterm birth. Specific phosphatidylcholine subtypes exert their protective effects against preterm birth through an ADA-dependent pathway. The mediation effect was -0.005 (95% CI -0.01 to -0.001). This finding not only deepens our understanding of the inflammatory origins of preterm birth but also provides direct evidence for the development of precision prevention strategies based on the regulation of the lipid-inflammation axis.