Adiponectin-receptor agonism prevents right ventricular tissue pathology in a mouse model of Duchenne muscular dystrophy
Our discoveries demonstrate early-stage cardiac tissue pathology occurs in a chamber-specific manner and is prevented by adiponectin receptor agonism, thereby opening a new direction for developing therapies that prevent tissue remodeling during DMD.
Authors
- Jeremy A. Simpson (ORCID: https://orcid.org/0000-0003-4482-547X)
- Luca J. Delfinis (ORCID: https://orcid.org/0000-0002-5472-6064)
- Brian Morris (ORCID: https://orcid.org/0000-0003-4439-0795)
- Ali A. Abdul‐Sater (ORCID: https://orcid.org/0000-0002-0022-0930)
- Henry H. Hsu (ORCID: https://orcid.org/0009-0002-8018-2651)
- Aditya N. Brahmbhatt (ORCID: https://orcid.org/0009-0003-0799-014X)
- Joe Quadrilatero (ORCID: https://orcid.org/0000-0002-9304-3557)
- Parashar D Bhatt
- Catherine A. Bellissimo (ORCID: https://orcid.org/0000-0002-7895-0271)
- Madison C. Garibotti
- Fasih A. Rahman (ORCID: https://orcid.org/0000-0003-4588-5378)
- Gary Sweeney (ORCID: https://orcid.org/0000-0002-1946-1347)
- Christopher G. R. Perry (ORCID: https://orcid.org/0000-0002-5745-5888)
- Amireza Goli
- Shivam Gandhi
- Peter H. Backx (ORCID: https://orcid.org/0000-0003-0497-776X)
- Simona Yakobov-Shimonov
Institutions
- University of Waterloo (CA)
- Bellevue College (US)
- York University (CA)
- University of Guelph (CA)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1016/j.molmet.2025.102179
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- James H. Cummings Foundation
- Heart and Stroke Foundation of Canada
- Ontario Research Foundation
- Canada Foundation for Innovation
- Canada Research Chairs
- Mitacs
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada