Impact of immune-related adverse events on quality of life and physical functioning in older patients with solid tumors treated with immune checkpoint inhibitors
Severe irAEs were not associated with unfavorable immunotherapy outcomes, regardless of frailty status. However, frailty was associated with unfavorable outcomes.
Authors
- Astrid A.M. van der Veldt (ORCID: https://orcid.org/0000-0003-0446-1907)
- Karlijn de Joode (ORCID: https://orcid.org/0000-0001-5928-2899)
- Johanneke E.A. Portielje (ORCID: https://orcid.org/0000-0002-5169-6306)
- Ellen Kapiteijn (ORCID: https://orcid.org/0000-0002-4814-6426)
- Cynthia Holterhues
- Nienke A. de Glas (ORCID: https://orcid.org/0000-0001-8350-4252)
- Anna Uit den Boogaard (ORCID: https://orcid.org/0009-0001-8427-8135)
- Marije Slingerland (ORCID: https://orcid.org/0000-0002-4181-8656)
- Geert Labots
- Els M.E. Verdegaal (ORCID: https://orcid.org/0000-0002-4449-8707)
- Hans M. Westgeest (ORCID: https://orcid.org/0000-0002-5735-3638)
- Thomas Tigges
- Ron H.J. Mathijssen (ORCID: https://orcid.org/0000-0001-5667-5697)
- Frederiek van den Bos (ORCID: https://orcid.org/0000-0003-1426-3509)
- Stella Trompet (ORCID: https://orcid.org/0000-0001-5006-0528)
- Simon P. Mooijaart (ORCID: https://orcid.org/0000-0003-3106-3568)
- A. Özkan (ORCID: https://orcid.org/0000-0002-6729-9479)
- Stephanie M. Zunder
Institutions
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- Amphia Ziekenhuis (NL)
- Oncode Institute (NL)
- Haga Hospital (NL)
- Helse Førde (NO)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1016/j.ejca.2025.115568
- Citations
- 5
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 6.12
Funders
- Universiteit Leiden
- ZonMw
- Leids Universitair Medisch Centrum