Pentazocine Pharmacodynamics in Children: Simulations to Assess Safety and Effectiveness
This pharmacokinetic-pharmacodynamic modeling study supports a 6-h dosing interval for pentazocine at 0.5 mg/kg in children. This interval strikes a balance between achieving effective analgesia and minimizing the risk of respiratory depression.
Authors
- Takayuki Omori
- Yasuhiro Tsuji (ORCID: https://orcid.org/0000-0002-7967-2947)
- Takahiko Aoyama (ORCID: https://orcid.org/0000-0001-6111-8537)
Institutions
- Nihon University (JP)
- Nihon Pharmaceutical University (JP)
- St. Luke's International Hospital (JP)
Publication Details
- Journal
- Pediatric Anesthesia
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1111/pan.15135
- Citations
- 1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.39