Timing and intraindividual variability of daytime napping and Alzheimer’s disease in older adults
Our findings suggest that specific timing patterns and irregularities in daytime napping are linked to Alzheimer's disease risk and pathology. Multi-dimensional assessments of nap behaviors may aid in risk stratification for neurocognitive impairment and offer a potential target for interventions aimed at promoting healthy cognitive aging.
Authors
- Chenlu Gao (ORCID: https://orcid.org/0000-0001-7162-8303)
- Agustín M. Ibáñez (ORCID: https://orcid.org/0000-0001-6758-5101)
- Ruixue Cai (ORCID: https://orcid.org/0000-0001-8641-0753)
- Aron S. Buchman (ORCID: https://orcid.org/0000-0002-6426-2742)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0002-9482-1752)
- Yue Leng (ORCID: https://orcid.org/0000-0001-5826-4031)
- Kun Hu (ORCID: https://orcid.org/0000-0003-0350-3132)
- Lei Gao (ORCID: https://orcid.org/0000-0003-1476-1460)
- Peng Li (ORCID: https://orcid.org/0000-0002-4684-4909)
- Lei Yu (ORCID: https://orcid.org/0000-0002-0237-8758)
- Xi Zheng (ORCID: https://orcid.org/0009-0001-9847-7063)
- David A. Bennett
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Rush University Medical Center (US)
- Harvard University (US)
- University of California, San Francisco (US)
- Trinity College Dublin (IE)
- Adolfo Ibáñez University (CL)
- University of San Andrés (AR)
- Massachusetts General Hospital (US)
- Circadian (United States) (US)
- Center for Pain and the Brain (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1038/s43856-025-00936-1
- Citations
- 3
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.35
Funders
- Alzheimer's Association
- Massachusetts General Hospital
- BrightFocus Foundation
- American Academy of Sleep Medicine Foundation
- Agencia Nacional de Investigación y Desarrollo
- National Institutes of Health
- Brigham Research Institute
- Fogarty International Center
- Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias