Efficacy and safety of human fibrinogen concentrate (BT524) in patients with major haemorrhage undergoing major orthopaedic or abdominal surgery (AdFIrst): a randomised, active-controlled, multicentre, partially blinded, phase 3 non-inferiority trial

Authors

Ashok Roy (ORCID: https://orcid.org/0000-0001-5641-8260)
Ümniye Balaban (ORCID: https://orcid.org/0000-0001-8591-4909)
Silke Aigner (ORCID: https://orcid.org/0009-0003-1285-1662)
Alexander Staus
Thomas Häder
Semhar Abraha (ORCID: https://orcid.org/0000-0002-3581-8959)
Heike Böhm
Sonja Schimo (ORCID: https://orcid.org/0009-0004-8392-4715)
Niels Rahe‐Meyer (ORCID: https://orcid.org/0000-0003-1302-8259)
Hans Trouillier
Jörg Schüttrumpf (ORCID: https://orcid.org/0000-0002-8855-4096)
Judith Wessels-Kranz

Institutions

Hampshire Hospitals NHS Foundation Trust (GB)
München Klinik Schwabing (DE)
Biotest (Germany) (DE)
Grifols (Spain) (ES)
Francis Hospital (DE)
Median SCP (Spain) (ES)
Ludwig-Maximilians-Universität München (DE)

Publication Details

Journal: EClinicalMedicine
Published: 2025-06-07
DOI: https://doi.org/10.1016/j.eclinm.2025.103264
Citations: 2
Primary Topic: Trauma, Hemostasis, Coagulopathy, Resuscitation
Type: article
Field-Weighted Citation Impact: 3.09

Funders

Medizinischen Hochschule Hannover
Technische Universität München
Grifols

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article

Efficacy and safety of human fibrinogen concentrate (BT524) in patients with major haemorrhage undergoing major orthopaedic or abdominal surgery (AdFIrst): a randomised, active-controlled, multicentre, partially blinded, phase 3 non-inferiority trial

Ashok Roy, Ümniye Balaban, Silke Aigner, Alexander Staus et al.

Jun 7, 2025

2 citations

EClinicalMedicine

Trauma, Hemostasis, Coagulopathy, Resuscitation

3.09

article

Efficacy and safety of human fibrinogen concentrate (BT524) in patients with major haemorrhage undergoing major orthopaedic or abdominal surgery (AdFIrst): a randomised, active-controlled, multicentre, partially blinded, phase 3 non-inferiority trial

Ashok Roy, Ümniye Balaban, Silke Aigner, Alexander Staus, Thomas Häder, Semhar Abraha, Heike Böhm, Sonja Schimo, Niels Rahe‐Meyer, Hans Trouillier, Jörg Schüttrumpf, Judith Wessels-Kranz

June 7, 2025article en

2 citations

Abstract

No abstract available for this paper.

EClinicalMedicineVol. 85

Hampshire Hospitals NHS Foundation Trust (GB), München Klinik Schwabing (DE), Biotest (Germany) (DE), Grifols (Spain) (ES), Francis Hospital (DE), Median SCP (Spain) (ES), Ludwig-Maximilians-Universität München (DE)

Medizinischen Hochschule Hannover, Technische Universität München, Grifols

Good health and well-being

Openalex Percentile: Top 10%

Trauma, Hemostasis, Coagulopathy, Resuscitation

3.09

DOI Open Access PDF OpenAlex

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