Performance of Galactomannan, Aspergillus-PCR, and Metagenomic sequencing for the diagnosis of invasive pulmonary aspergillosis in hematological patients
BALF is critical for accurate IPA diagnosis, particularly in patients with prior antifungal therapy. BALF Aspergillus-PCR offers optimal sensitivity, while blood-based mNGS and PCR are recommended for neutropenic and non-neutropenic patients, respectively. Combining molecular methods with GM testing enhances diagnostic performances. Tailored strategies are essential to improve early detection and clinical outcomes in high-risk hematologic populations.
Authors
- Guoqing Zhu (ORCID: https://orcid.org/0000-0002-0371-6042)
- Sizhou Feng (ORCID: https://orcid.org/0000-0001-5304-3301)
- Erlie Jiang (ORCID: https://orcid.org/0000-0003-0237-6063)
- Chunhui Xu (ORCID: https://orcid.org/0000-0002-3836-3179)
- Yuetian Yu (ORCID: https://orcid.org/0000-0002-0193-4046)
- Yuyan Shen (ORCID: https://orcid.org/0000-0002-8007-6819)
- Yuping Fan (ORCID: https://orcid.org/0000-0003-3929-132X)
- Xin Chen (ORCID: https://orcid.org/0000-0002-8344-4023)
- Teng Liu (ORCID: https://orcid.org/0000-0002-2185-7260)
- Lining Zhang (ORCID: https://orcid.org/0000-0001-8267-1825)
- Yuanyuan Shi (ORCID: https://orcid.org/0000-0002-1229-8110)
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
Publication Details
- Journal
- Journal of Microbiology Immunology and Infection
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1016/j.jmii.2025.06.001
- Citations
- 2
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- Peking Union Medical College
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- Chinese Academy of Medical Sciences Initiative for Innovative Medicine