Adaptation of plateau frog peptide: From antimicrobial to angiogenic and proliferative functions
SC17-2 represents a unique functional divergence in amphibian peptides, driven by ecological adaptation rather than microbial pressure. Its ability to promote angiogenesis and cell migration highlights its potential as a novel therapeutic agent for regenerative medicine, shaped by the extreme conditions of the Tibetan Plateau.
Authors
- Kaixun Cao
- Qiumin Lu
- Jinai Gao (ORCID: https://orcid.org/0000-0002-3832-5009)
- Congyue Deng (ORCID: https://orcid.org/0000-0002-0177-218X)
- Hui Cao (ORCID: https://orcid.org/0000-0003-3406-3803)
- Xiaoshan Huang (ORCID: https://orcid.org/0000-0002-2853-7219)
- Yizhe Cheng (ORCID: https://orcid.org/0000-0002-9619-748X)
- Qian Chen (ORCID: https://orcid.org/0000-0003-1538-7693)
- Liting Zhang (ORCID: https://orcid.org/0000-0001-5175-1873)
- Min Yang
- Shouyi Gao
- Ren Lai
Institutions
- Nanjing Agricultural University (CN)
- Kunming Institute of Zoology (CN)
- University of Macau (MO)
- Shenzhen Academy of Robotics (CN)
- Yuntianhua Group (China) (CN)
- Ministry of Agriculture (CA)
- Guangdong Provincial Academy of Environmental Science (CN)
- Ministry of Agriculture and Rural Affairs (CN)
- Shenzhen Academy of Aerospace Technology (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1016/j.jare.2025.06.013
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00