Development and characterization of endolysosomal trafficking targeting chimera degraders of α1A-adrenergic receptor
Proof-of-concept studies of the ETTAC degraders for GPCR successfully elucidate the roles of post-endocytic sorting proteins and applied to directing the lysosomal degradation of α<sub>1A</sub>-ARs. Consequently, the ETTAC strategy represents a promising approach for the selective degradation of GPCRs and paves the way for future drug development.
Authors
- Tong Li (ORCID: https://orcid.org/0000-0001-5947-1884)
- Minyong Li (ORCID: https://orcid.org/0000-0003-3276-4921)
- Xiayi Ke
- Lüpei Du (ORCID: https://orcid.org/0000-0003-0531-8985)
- Zhao Ma (ORCID: https://orcid.org/0000-0002-8000-5324)
- Wenhua Li (ORCID: https://orcid.org/0000-0003-2098-1742)
- Shuo Wang (ORCID: https://orcid.org/0000-0002-4301-6518)
- Jiwei Chen (ORCID: https://orcid.org/0000-0003-4202-816X)
Institutions
- Shandong University (CN)
- Hainan University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1016/j.jare.2025.06.014
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Taishan Scholar Foundation of Shandong Province
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Taishan Scholar Foundation of Shandong Province
- Taishan Scholar Project of Shandong Province