An in-silico analysis of the influence of left bundle branch block and myocardial fibrosis on electrocardiographic QRS duration and morphology and vectorcardiographic QRS area
A LBBB activation, and not myocardial fibrosis, induces a large QRS area. In the presence of LBBB, myocardial fibrosis cannot be clearly identified with QRS morphology and has a limited effect on QRS duration but significantly reduces QRS area.
Authors
- Uyên Châu Nguyên (ORCID: https://orcid.org/0000-0002-4836-2946)
- Antonius van Stipdonk (ORCID: https://orcid.org/0000-0002-6621-0727)
- Karin C. Smits (ORCID: https://orcid.org/0000-0001-6352-5769)
- Joost Lumens (ORCID: https://orcid.org/0000-0001-8129-7384)
- Kevin Vernooy (ORCID: https://orcid.org/0000-0002-8818-5964)
- Frits W. Prinzen (ORCID: https://orcid.org/0000-0001-8917-9032)
- Johan van Koll (ORCID: https://orcid.org/0009-0000-7892-7074)
- Muhammet Dural (ORCID: https://orcid.org/0000-0001-7227-8114)
- Peter van Dam (ORCID: https://orcid.org/0000-0002-7962-1760)
- Justin Luermans (ORCID: https://orcid.org/0000-0001-9598-2286)
- Ted E.M. Lempers
Institutions
- Jagiellonian University (PL)
- Maastricht University Medical Centre (NL)
- Maastricht University (NL)
- Eskişehir Osmangazi University (TR)
Publication Details
- Journal
- Journal of Electrocardiology
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1016/j.jelectrocard.2025.154043
- Primary Topic
- Cardiac pacing and defibrillation studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Abbott Laboratories
- Medtronic
- Hartstichting
- Biotronik
- Cordis