hUMSC-derived exosomes alleviate follicular interstitial cell autophagy by let-7a-5p/AMPK/mTOR axis in POI rats
Overall, the findings suggested that hUMSC-Exos improves ovarian function in POI rats by inhibiting TICs autophagy via the let-7a-5p/AMPK/mTOR pathway. Our study provided further evidence that POI patients can benefit from hUMSC-Exos-mediated therapy.
Authors
- Haoyu Huang
- Yanlian Xiong (ORCID: https://orcid.org/0000-0001-5178-8932)
- Yu He
- Hongchu Bao (ORCID: https://orcid.org/0000-0002-5888-5484)
- Feibo Xu (ORCID: https://orcid.org/0000-0001-9306-5521)
- Yu Tang
- Yixuan Meng (ORCID: https://orcid.org/0000-0002-4047-3385)
- Lianshuang Zhang (ORCID: https://orcid.org/0000-0002-6513-0821)
- Yukun Zhang (ORCID: https://orcid.org/0000-0002-3557-0498)
- Xingyu Huo
- Juntong Chen
- Maojiao Qian
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Shandong University of Aeronautics (CN)
- Yuhuangding Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1186/s13287-025-04396-1
- Citations
- 3
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- National Natural Science Foundation of China