Pharmacokinetics and Pharmacodynamics of Intranasal Diacetylmorphine in Heroin-Assisted Treatment for Severe Opioid Use Disorder
IN DAM has a good safety profile and should be considered as an effective alternative for patients in HAT, offering rapid onset of effects without significant side effects. Optimization of intranasal delivery may further improve absorption and clinical utility.
Authors
- Urs Duthaler
- Kenneth M. Dürsteler (ORCID: https://orcid.org/0000-0003-1552-5822)
- Dino Luethi (ORCID: https://orcid.org/0000-0003-0874-4875)
- Marc Vogel (ORCID: https://orcid.org/0000-0002-3088-0331)
- Jan Thomann (ORCID: https://orcid.org/0000-0003-3820-2671)
- Matthias E. Liechti (ORCID: https://orcid.org/0000-0002-1765-9659)
- Maximilian Meyer (ORCID: https://orcid.org/0000-0003-1183-1195)
- Jean N. Westenberg (ORCID: https://orcid.org/0000-0002-4720-8402)
- Severin B. Vogt (ORCID: https://orcid.org/0009-0007-3650-3549)
- Adrian Guessoum
- Benjamin Klemperer
Institutions
- University of Basel (CH)
- University Hospital of Basel (CH)
- Universitäre Psychiatrische Kliniken Basel (CH)
Publication Details
- Journal
- CNS Drugs
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1007/s40263-025-01189-1
- Primary Topic
- Opioid Use Disorder Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universität Basel
- Bundesamt für Gesundheit