Palladium-Catalyzed [4 + 1] Annulation of Benzofuran-Derived Azadienes with Isocyanides
A palladium-catalyzed [4 + 1] annulation of benzofuran-derived azadienes and isocyanides has been developed. This protocol provides an efficient and practical approach to obtain diverse benzofuro[3,2-<i>b</i>]pyrrole derivatives in moderate to good yields. The reaction appears to proceed through Pd<sup>II</sup>-assisted intramolecular Michael addition, followed by 5-<i>exo-dig</i> cyclization, aromatization, and subsequent base-assisted desulfonylation.
Authors
- Qingqing Wu (ORCID: https://orcid.org/0000-0003-1513-3191)
- Bingchuan Yang (ORCID: https://orcid.org/0000-0003-1195-5833)
- Puyu Zhang (ORCID: https://orcid.org/0000-0002-6515-4575)
- Ruoyu Zhang (ORCID: https://orcid.org/0000-0002-3502-8738)
- Pan Li (ORCID: https://orcid.org/0000-0001-6658-9207)
- Jingjing Zhao
- Yun Chai
- X. H. Xie (ORCID: https://orcid.org/0009-0008-5229-8431)
Institutions
- Henan University (CN)
- Qilu Normal University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1021/acs.joc.5c00769
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China