Impact of solar irradiation on lipidome dynamics and disruption using an in vitro 3D reconstructed epidermis model and a combination of advanced analytical methods
A combination of LC-MS/MS and MALDI-MSI enabled the analysis of lipids involved in key pathways altered by irradiation, as well as their location in the epidermis. Importantly, the SPF50+ sunscreen exhibited a protective effect on the epidermis lipidome against modulations due to irradiation. This technology will enable biomarker and pathway-specific events in the epidermis to be monitored after different treatments.
Authors
- Maureen Feucherolles (ORCID: https://orcid.org/0000-0002-2052-8975)
- Carine Jacques (ORCID: https://orcid.org/0000-0001-6839-6417)
- Jérôme Bour (ORCID: https://orcid.org/0009-0008-9961-5553)
- Gautier Doat (ORCID: https://orcid.org/0009-0008-2256-1251)
- Hélène Duplan (ORCID: https://orcid.org/0000-0001-9414-8070)
- Gilles Frache (ORCID: https://orcid.org/0000-0003-0069-9475)
- William Le
- C. Boudet
Institutions
- Luxembourg Institute of Science and Technology (LU)
- Pierre Fabre (France) (FR)
Publication Details
- Journal
- International Journal of Cosmetic Science
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1111/ics.13077
- Primary Topic
- Advancements in Transdermal Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Les Laboratories Pierre Fabre