Surgical considerations for tumour-infiltrating lymphocyte therapy in melanoma: results from a randomized phase III trial
Tumour resections for TIL-IMP manufacture lead to limited surgical complications. Manufacture with a therapeutic response was successful using lesions of varying sizes from different anatomical locations, with highest rates for lymph nodes.
Authors
- Yvonne Schrage (ORCID: https://orcid.org/0000-0001-7065-514X)
- Koen J. Hartemink (ORCID: https://orcid.org/0000-0003-4282-1096)
- Tom Seijkens (ORCID: https://orcid.org/0000-0001-6370-1267)
- John B.A.G. Haanen (ORCID: https://orcid.org/0000-0001-5884-7704)
- Marco Donia (ORCID: https://orcid.org/0000-0003-4966-9752)
- Sebastian Klobuch (ORCID: https://orcid.org/0000-0003-1364-0763)
- Cynthia M. Nijenhuis
- Marie Brinch-Møller Weitemeyer (ORCID: https://orcid.org/0000-0002-4452-8849)
- Ferry Lalezari (ORCID: https://orcid.org/0000-0002-1777-3259)
- Troels Holz Borch (ORCID: https://orcid.org/0000-0002-4402-9281)
- Inge Marie Svane (ORCID: https://orcid.org/0000-0002-9451-6037)
- Carlijn Voermans (ORCID: https://orcid.org/0000-0002-6345-9746)
- Maartje W. Rohaan (ORCID: https://orcid.org/0000-0003-1470-9427)
- Michel W.J.M. Wouters (ORCID: https://orcid.org/0000-0001-6173-0662)
- Liselotte Tas
- Özcan Met (ORCID: https://orcid.org/0000-0002-3256-7592)
- Winan J. van Houdt (ORCID: https://orcid.org/0000-0002-2303-3468)
- Lisbet Rosenkrantz Hölmich (ORCID: https://orcid.org/0000-0002-1983-5222)
- Inge Jedema (ORCID: https://orcid.org/0000-0001-9042-6459)
- Bastiaan Nuijen (ORCID: https://orcid.org/0000-0002-8652-3560)
- Anke Kuijpers
- Maaike van Zon
- Marten Hansen (ORCID: https://orcid.org/0000-0003-1379-2759)
- Niels F. M. Kok (ORCID: https://orcid.org/0000-0003-1193-0214)
- Alexander C J van Akkooi
Institutions
- Leiden University (NL)
- The University of Sydney (AU)
- Dutch Cancer Society (NL)
- Royal Prince Alfred Hospital (AU)
- Leiden University Medical Center (NL)
- Centre Hospitalier Universitaire Vaudois (CH)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- The Netherlands Cancer Institute (NL)
- Sanquin (NL)
- Oncode Institute (NL)
- Melanoma Institute Australia (AU)
Publication Details
- Journal
- British journal of surgery
- Published
- 2025-05-31
- DOI
- https://doi.org/10.1093/bjs/znaf090
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Amgen
- Bristol-Myers Squibb
- Pfizer
- AstraZeneca
- Sanofi
- Kræftens Bekæmpelse
- Les Laboratories Pierre Fabre
- SkylineDx
- ZonMw
- Gentofte Hospital
- Eisai
- KWF Kankerbestrijding
- Region Hovedstaden
- Ipsen
- Genentech
- Merck Sharp and Dohme
- Sanofi Pasteur