Keratinocyte necroptosis promotes the progression of radiation-induced oral mucositis
This study provides evidence that RIPK3/MLKL-mediated necroptosis in keratinocytes contributes to the pathogenesis of RIOM. Inhibiting this pathway reduces cell death and inflammation, suggesting a promising therapeutic target for the treatment of RIOM.
Authors
- Huacong Huang
- Xiaoyu Li (ORCID: https://orcid.org/0009-0006-9840-6704)
- Xingzhu Dai (ORCID: https://orcid.org/0000-0003-2373-0842)
- Wanghong Zhao (ORCID: https://orcid.org/0000-0001-5764-151X)
- Yuee Liang
- Manqiong Dai
Institutions
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1186/s12903-025-06278-7
- Citations
- 4
- Primary Topic
- Oral health in cancer treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province