Serotonin release mediates analgesia via opioidergic system and withdrawal symptoms in chronic kratom extract-treated mice
Kratom extracts have the potential to provide analgesic effects and withdrawal symptoms, both of which are mediated by elevated serotonin release.
Authors
- Asep Bayu (ORCID: https://orcid.org/0000-0002-5693-0501)
- Peni Ahmadi (ORCID: https://orcid.org/0000-0003-0865-3420)
- Anissa Nofita Sari (ORCID: https://orcid.org/0000-0003-3634-8167)
- Siti Irma Rahmawati (ORCID: https://orcid.org/0000-0001-5376-7860)
- Ni Luh Putu Indi Dharmayanti (ORCID: https://orcid.org/0000-0002-9399-8193)
- Dwi Wahyu Indriani (ORCID: https://orcid.org/0000-0003-0470-5289)
- Masteria Yunovilsa Putra (ORCID: https://orcid.org/0000-0002-9879-3293)
- Zuraida Zuraida (ORCID: https://orcid.org/0000-0001-7353-321X)
Institutions
- Center for Plant Conservation (US)
- University of Indonesia (ID)
- Center for Indonesian Veterinary Analytical Studies (ID)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1186/s12906-025-04947-2
- Citations
- 2
- Primary Topic
- Alkaloids: synthesis and pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- Badan Riset dan Inovasi Nasional