Impact of irae characteristics on efficacy of consolidative immunotherapy following chemoradiotherapy in locally advanced NSCLC
Occurrence of irAEs, particularly late-onset, single-system, or grade 1-2 correlated with greater benefit from consolidative PD-L1 inhibitors in LA-NSCLC. Conversely, severe irAEs predict poorer survival, even compared to no ICI consolidation. Elevated CD103<sup>+</sup>CD8<sup>+</sup> T cell infiltration may serve as a biomarker to identify patients at risk of severe irAEs who may not benefit from immunoconsolidation therapy.
Authors
- Xiufen Wang (ORCID: https://orcid.org/0000-0002-3541-740X)
- Yuping Sun (ORCID: https://orcid.org/0000-0002-0804-6850)
- Juan Li (ORCID: https://orcid.org/0000-0002-0992-2699)
- Leirong Wang
- Aiqin Gao (ORCID: https://orcid.org/0009-0009-3596-6669)
- Jian Zhang (ORCID: https://orcid.org/0000-0001-7217-0111)
- Haodong Sun
- Zhen Wang (ORCID: https://orcid.org/0009-0005-2912-1847)
- Dahai Wang (ORCID: https://orcid.org/0000-0001-5488-4831)
- Shuyun Wang (ORCID: https://orcid.org/0009-0000-2519-8875)
- Xuebing Fu
- Qiaohong Liu
- Yanxin Sun
- Yihui Ge
- Yiling Gan
Institutions
- Shandong University (CN)
- Jinan Central Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- BMC Pulmonary Medicine
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1186/s12890-025-03742-6
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Gilead Sciences
- Jinan Science and Technology Bureau
- Beijing Xisike Clinical Oncology Research Foundation
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Shandong First Medical University
- Shandong Academy of Medical Sciences
- Wu Jieping Medical Foundation
- Key Technology Research and Development Program of Shandong
- Beijing Science and Technology Planning Project