A nationwide experience of biological treatments in children with eosinophilic esophagitis
Pending marketing authorization, biological therapies for pediatric eosinophilic esophagitis are mainly prescribed after failure of first-line treatments and on a compassionate basis in France. Dupilumab is the biotherapy most frequently used, is associated with clinical and histological efficacy and is well-tolerated. Children and adolescents requiring biologics appear to be younger and more severe at diagnosis than naive pediatric patients in Europeans registries.
Authors
- C. Hoarau (ORCID: https://orcid.org/0000-0003-1794-0659)
- Léa Chantal Tran
- Madeleine Aumar (ORCID: https://orcid.org/0000-0002-2908-6931)
- Raphaël Enaud (ORCID: https://orcid.org/0000-0001-9493-5218)
- Stéphanie Lejeune (ORCID: https://orcid.org/0000-0001-7009-2113)
- L. Bridoux‐Henno
- Mathilde Butori
- Alexandre Fabre (ORCID: https://orcid.org/0000-0001-5155-6437)
- Frédèric Gottrand (ORCID: https://orcid.org/0000-0002-5290-0436)
- A. Lemoine (ORCID: https://orcid.org/0000-0001-8443-7207)
- Marjorie Bonneton
- Georges Dimitrov (ORCID: https://orcid.org/0009-0006-5852-7624)
- Nicolas Caron (ORCID: https://orcid.org/0000-0003-3782-4452)
- Nicolas Kalach (ORCID: https://orcid.org/0000-0003-4525-0276)
- Julie Rebeuh
- Hélène Lengline
- Claire Dupont (ORCID: https://orcid.org/0000-0002-7355-6515)
- J Soudant
- Émeline Caillau
Institutions
- Inserm (FR)
- Université Catholique de Lille (FR)
- Aix-Marseille Université (FR)
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Sorbonne Université (FR)
- Hôpital Femme Mère Enfant (FR)
- Hôpital Armand-Trousseau (FR)
- Assistance Publique Hôpitaux de Marseille (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hospices Civils de Lyon (FR)
- Hôpital Jeanne de Flandre (FR)
- Bordeaux Population Health (FR)
- Délégation Centre-Est (FR)
- Hôpital Robert-Debré (FR)
- Lille Inflammation Research International Center (FR)
- Fondation Lenval (FR)
- Groupe Hospitalier de l'Institut Catholique de Lille (FR)
- Centre hospitalier universitaire d'Orléans (FR)
- Centre Hospitalier Universitaire de Rennes (FR)
- Institute for Translational Research in Inflammation (FR)
- Université de Rennes (FR)
- Université de Strasbourg (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1038/s41390-025-04011-2
- Primary Topic
- Eosinophilic Esophagitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centre hospitalier régional universitaire de Lille