Sex-specific and metabolic subgroup heterogeneity in high-density lipoprotein cholesterol associations with diabetic kidney disease risk: a retrospective cohort study
This study reveals sex- and metabolic context-dependent heterogeneity in HDL-C-DKD associations: males and short-duration diabetes exhibited threshold effects (0.93 mmol/L), females showed continuous protection, and subgroups with hypertension, poorly controlled glycemia, or obesity (BMI > 28 kg/m²) exhibited both continuous protection and threshold effects. These findings may inform individualized risk stratification in specific populations.
Authors
- Yongjun Ma (ORCID: https://orcid.org/0000-0001-9165-7371)
- Meili Lin
- Fang‐Ju Lin (ORCID: https://orcid.org/0000-0002-8249-7481)
- Xiance Jin (ORCID: https://orcid.org/0000-0002-4117-5953)
- Guangming Chen (ORCID: https://orcid.org/0000-0002-5353-2655)
- Huabin Wang (ORCID: https://orcid.org/0000-0002-9090-7380)
Institutions
- Wenzhou Medical University (CN)
- Jinhua Academy of Agricultural Sciences (CN)
- Guang Fu Hospital (CN)
- Community Health Center (US)
- Jinhua Central Hospital (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1186/s12944-025-02632-4
- Citations
- 3
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.88
Funders
- Zhejiang University
- Jinhua Science and Technology Bureau