Reconstructing rearrangement phylogenies of natural genomes
We benchmark our method on simulated and real data. On simulated phylogenies we observe a considerable performance improvement on problems that include linear chromosomes. And even when the ground truth contains only one circular chromosome per genome, our method outperforms its predecessor due to its optimized handling of the solution space. The practical advantage becomes also visible in an analysis of seven Anopheles taxa.
Authors
- Leonard Bohnenkämper (ORCID: https://orcid.org/0000-0003-4508-0078)
- Jens Stoye (ORCID: https://orcid.org/0000-0002-4656-7155)
- Daniel Doerr (ORCID: https://orcid.org/0000-0002-3720-6227)
Institutions
- Bielefeld University (DE)
- Hochschule Bielefeld (DE)
- Düsseldorf University Hospital (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Algorithms for Molecular Biology
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1186/s13015-025-00279-5
- Primary Topic
- Genome Rearrangement Algorithms
- Type
- article
- Field-Weighted Citation Impact
- 0.00