Power and sample size calculation for non-inferiority trials with treatment switching in intention-to-treat analysis comparing RMSTs
This simulation-based approach provides power and sample size calculation in NI trials with treatment switching, when comparing the RMSTs of two treatment groups in ITT analysis. With its comprehensive parameter settings, nifts will be useful for designing NI trials that allow for treatment switching. nifts is freely available at https://github.com/cyhsuTN/nifts .
Authors
- Yu Shyr (ORCID: https://orcid.org/0000-0003-2086-9670)
- Chih‐Hung Hsu (ORCID: https://orcid.org/0000-0003-0495-973X)
- A. Shih (ORCID: https://orcid.org/0009-0009-4067-0512)
Institutions
- Vanderbilt University (US)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1186/s12874-025-02604-3
- Citations
- 1
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 2.63
Funders
- National Institutes of Health