Type 2 diabetes worsens the outcome of ischemia/reperfusion in female STEMI patients and female db/db mice with HFpEF cardiometabolic phenotype
In diabetic women, multiple factors beyond reperfusion delays exacerbate acute myocardial injury. This necessitates the development of sex-specific strategies to manage the cardiovascular complications of diabetic HFpEF. The db/db mouse model provides a relevant preclinical tool for future research as it mimics human T2D-associated HFpEF and STEMI outcome.
Authors
- Elvira Corhodzic
- Fenn Cullen
- Dunja Aksentijević (ORCID: https://orcid.org/0000-0002-8480-6727)
- Megan Young (ORCID: https://orcid.org/0000-0001-7777-3966)
- Michael P. Murphy (ORCID: https://orcid.org/0000-0003-1115-9618)
- Ivana Iveljić (ORCID: https://orcid.org/0000-0001-8927-5390)
- Hiran A. Prag (ORCID: https://orcid.org/0000-0002-4753-8567)
Institutions
- University of Tuzla (BA)
- Queen Mary University of London (GB)
- University of Cambridge (GB)
- University Clinical Center Tuzla (BA)
- William Harvey Research Institute (GB)
- MRC Mitochondrial Biology Unit (GB)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1186/s12933-025-02771-z
- Citations
- 3
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- Queen Mary University of London
- Wellcome Trust
- Barts Charity
- Medical Research Council