Effect of luteolin on ceftiofur intestinal absorption: the rational use of Caco-2 monolayer cell model and everted gut sac model
Luteolin increased ceftiofur intestinal absorption by downregulating the transcription and translation level of MRP2 or tight junction proteins (Occludin, Claudin-1, and ZO-1), supporting its role as an oral bioavailability enhancer.
Authors
- Yuru Guo (ORCID: https://orcid.org/0000-0003-0093-8368)
- Chunlian Tian (ORCID: https://orcid.org/0000-0002-2298-5838)
- Limei Han (ORCID: https://orcid.org/0009-0000-8396-4603)
- Zhiruo Kang
- Ruxia Wang
- Shengli Niu (ORCID: https://orcid.org/0000-0002-6961-943X)
- Min Li (ORCID: https://orcid.org/0000-0003-4847-2341)
- Zehui Zhang (ORCID: https://orcid.org/0000-0002-2641-4733)
- Mingchun Liu (ORCID: https://orcid.org/0000-0002-1109-3965)
Institutions
- Shenyang Agricultural University (CN)
- Liaoning University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Poultry Science
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1016/j.psj.2025.105409
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China