Prevalence, associated factors, and short-term impact of central sensitization in high-altitude patients undergoing total knee arthroplasty
This study found a 15.7% prevalence of CS among high-altitude TKA patients. Female gender, higher BMI, and residence at altitudes above 4,000 m were identified as factors associated with CS. Furthermore, CS was linked to worse short-term postoperative outcomes, including higher pain levels, increased incidence of PONV, greater opioid consumption, longer hospital stays, and a higher prevalence of chronic postoperative pain and dissatisfaction.
Authors
- Li Tan (ORCID: https://orcid.org/0000-0001-5961-0450)
- Sha Wan
- Siqing Zhang (ORCID: https://orcid.org/0000-0001-9927-1529)
- Xuemei Bai (ORCID: https://orcid.org/0000-0001-6556-8041)
- Kefu Lin
- Lang Li (ORCID: https://orcid.org/0000-0002-2946-7021)
- Zhen Tian (ORCID: https://orcid.org/0000-0001-7475-9472)
- Li Deng (ORCID: https://orcid.org/0000-0002-7357-8052)
- Meng Ding (ORCID: https://orcid.org/0000-0002-8874-0497)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Tibet Autonomous Region People's Hospital (CN)
Publication Details
- Journal
- International Orthopaedics
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1007/s00264-025-06560-x
- Citations
- 2
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33