Brain‐derived tau to measure treatment effect in Alzheimer's disease and frontotemporal dementia
Cerebrospinal fluid (CSF) brain-derived tau (BD-tau) levels decreased with sodium selenate treatment in patients with Alzheimer's disease (AD).CSF BD-tau levels did not change with sodium selenate treatment in bvFTD.Baseline CSF BD-tau correlated with CSF total tau (t-tau) and phosphorylated tau-181 (p-tau181) in AD and behavioral variant frontotemporal dementia (bvFTD).Baseline serum and plasma BD-tau levels did not correlate with CSF BD-tau in bvFTD.CSF p-tau217 did not change with sodium selenate treatment in AD or bvFTD.
Authors
- Cassandra Marotta (ORCID: https://orcid.org/0009-0008-8430-4824)
- Terence John O'Brien (ORCID: https://orcid.org/0000-0002-7198-8621)
- Michael Turton
- Fernando González‐Ortiz (ORCID: https://orcid.org/0000-0001-7897-9456)
- Benjamin Sinclair (ORCID: https://orcid.org/0000-0002-0850-3644)
- Lucy E. Vivash (ORCID: https://orcid.org/0000-0002-1182-0907)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Christopher M. Hovens (ORCID: https://orcid.org/0000-0002-0610-1289)
- Kaj Blennow
- Peter Harrison
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Hong Kong Science and Technology Parks Corporation (HK)
- Sahlgrenska University Hospital (SE)
- Victorian Comprehensive Cancer Centre (AU)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Alfred Health (AU)
- University College London (GB)
- Monash University (AU)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/dad2.70123
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Biogen
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- Royal Melbourne Hospital Neuroscience Foundation
- EU Joint Programme – Neurodegenerative Disease Research
- Australian Government
- European Partnership on Metrology
- National Institute for Health and Care Research
- University College London
- European Commission
- Eisai
- Hjärnfonden
- Vetenskapsrådet
- UK Dementia Research Institute
- Epilepsy Society
- National Institutes of Health
- HORIZON EUROPE Framework Programme
- Medical Research Council
- National Health and Medical Research Council
- UCB Pharma