Genetic deletion of microsomal prostaglandin E synthase-1 promotes imiquimod-induced psoriasis in mice
Our study results demonstrate that mPGES-1 is the main enzyme responsible for skin PGE<sub>2</sub> production, and that mPGES-1 deficiency facilitates the development of psoriasis by affecting the development of T-cell-mediated immunity. Therefore, mPGES-1 might impact both skin inflammation and T-cell-mediated immunity associated with psoriasis.
Authors
- Yoshiko Iizuka
- Yuka Hioki
- Takafumi Ichikawa
- Makoto Kubo (ORCID: https://orcid.org/0000-0002-6393-4017)
- Haruhito Adam Uchida (ORCID: https://orcid.org/0000-0002-7629-7678)
- Shiho Arichi
- Shotaro Maehana (ORCID: https://orcid.org/0009-0002-3187-2090)
- Miori Sumida
- Hitoshi Kashiwagi (ORCID: https://orcid.org/0000-0001-6385-9988)
- Fumiaki Kojima
- Kei Eto
Institutions
- Okayama University (JP)
- Hokkaido University (JP)
- Okayama University Hospital (JP)
- Kitasato University (JP)
Publication Details
- Journal
- Inflammation and Regeneration
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1186/s41232-025-00385-2
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kitasato University
- Japan Society for the Promotion of Science
- School of Allied Health Sciences, Kitasato University