Targeting Dicer reprograms tumor-associated macrophages to promote anti-tumoral immunity in colorectal cancer liver metastasis
Our study uncovered the central role of Dicer in the M2 polarization of TAMs, in turn suggesting a promising therapeutic strategy for CRLM.
Authors
- Tianhua Zhou (ORCID: https://orcid.org/0009-0001-5753-6434)
- Meng Xue
- Yuzhen Gao (ORCID: https://orcid.org/0000-0001-5907-8062)
- Zhengyang Xu (ORCID: https://orcid.org/0000-0001-7396-4968)
- Xuefei Zhou (ORCID: https://orcid.org/0000-0001-6521-0592)
- Jingyu Chen (ORCID: https://orcid.org/0000-0002-0563-9749)
- Xiaowei Liu (ORCID: https://orcid.org/0000-0002-4013-7197)
- Wenwen Chen (ORCID: https://orcid.org/0000-0003-0277-0941)
- Ying Zhang (ORCID: https://orcid.org/0000-0002-5812-372X)
- Ning Ding (ORCID: https://orcid.org/0000-0001-5726-1840)
- Shenglong Xia (ORCID: https://orcid.org/0000-0002-3661-8107)
Institutions
- Sir Run Run Shaw Hospital (CN)
- Ministry of Education (IR)
- Zhejiang Institute of Mechanical and Electrical Engineering (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1186/s12951-025-03518-4
- Citations
- 6
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Zhejiang Province