Mitochondrial mass and mitochondrial membrane potential of peripheral lymphocytes: promising biomarkers of systemic lupus erythematosus
Our data showed that patients with SLE exhibit mitochondrial dysfunction. Several MMP-Low and SCMM in CD8+T cell subsets could serve as potential biomarkers for diagnosing SLE. Additionally, CD4<sup>+</sup> Tcm MMP-Low and SCMM-CD3<sup>+</sup>CD4<sup>+</sup> T cells were associated with SLE disease activity.
Authors
- Hongyun Zhao (ORCID: https://orcid.org/0000-0002-1251-3888)
- Guanfei Zhao (ORCID: https://orcid.org/0000-0001-7794-3793)
- Yipei Jing
- Haolong Li (ORCID: https://orcid.org/0000-0002-1761-6907)
- Shasha Wang (ORCID: https://orcid.org/0000-0002-8724-4627)
- Rui Zhang (ORCID: https://orcid.org/0000-0003-1371-8567)
- Yuying Chen (ORCID: https://orcid.org/0000-0002-0557-9723)
- Yongzhe Li (ORCID: https://orcid.org/0000-0002-0046-5276)
- Yutong Miao (ORCID: https://orcid.org/0000-0003-1941-5997)
- Yuan Huang (ORCID: https://orcid.org/0009-0009-9363-7919)
- Linlin Cheng
- Yongmei Liu
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-06-06
- DOI
- https://doi.org/10.3389/fmolb.2025.1585847
- Citations
- 1
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 1.67