Insights into regulatory T-cell and type-I interferon roles in determining abacavir-induced hypersensitivity or immune tolerance
This study unveils novel immune mechanisms driven by drug and host-related factors required for <i>in vivo</i> reactions and sheds light on potential biomarker and therapeutic targets for managing and preventing severe and life-threatening iDHR.
Authors
- Maryam Khalaj
- Kirthiram Krishnaveni Sivakumar
- Marco Cardone
- Montserrat Puig (ORCID: https://orcid.org/0000-0001-8641-5706)
- Yura Jang (ORCID: https://orcid.org/0000-0002-1338-4686)
- Hratch Baghdassarian (ORCID: https://orcid.org/0000-0003-2739-8613)
- Sintayehu Gebreyohannes
- Kazuyo Takeda
- Nathan E. Lewis (ORCID: https://orcid.org/0000-0001-7700-3654)
- SuJin Hwang (ORCID: https://orcid.org/0000-0001-8531-4575)
- Michael A. Norcross
Institutions
- Center for Biologics Evaluation and Research (US)
- Center for Drug Evaluation and Research (US)
- La Jolla Bioengineering Institute (US)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1612451
- Citations
- 2
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.79