Bone biomarkers in post-polio clinic patients
While mean levels of all evaluated bone biomarkers were normal, PTH and sBTMs were significantly lower in post-polio patients with osteoporosis compared to controls, indicating reduced bone turnover. With bisphosphonate treatment, osteocalcin and C-telopeptide declined significantly in both groups, but significantly more in controls than in post-polio patients. These results indicate that BTM's could be useful for monitoring treatment response in post-polio patients.
Authors
- Seyed Pezhman Madani (ORCID: https://orcid.org/0000-0002-5442-2933)
- Richard Kremer (ORCID: https://orcid.org/0000-0002-7053-2139)
- Andrea Benedetti
- Ami Grunbaum (ORCID: https://orcid.org/0000-0001-8745-0036)
- Daria A. Trojan
- Shaddam Bagmar
Institutions
- Montreal Neurological Institute and Hospital (CA)
- McGill University Health Centre (CA)
- Royal Victoria Hospital (CA)
- McGill University (CA)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.3389/fendo.2025.1568981
- Primary Topic
- Orthopaedic implants and arthroplasty
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Montreal Neurological Institute and Hospital