The N-6 methyladenosine dynamics in STEMI and the effect of IL-6 inhibition - a hypothesis generating sub-study of the ASSAIL-MI trial
In this hypothesis generating study, m<sup>6</sup>A deposition differs STEMI patients and healthy controls. The m<sup>6</sup>A pattern changes over the course of 3-7 days. This response is, at least to some degree, is modulated by blocking the IL-6 receptor. Our data may suggest that this post-transcriptional regulation of RNA is involved in the immune response during STEMI, highlighting its potential as a target for therapy in MI.
Authors
- Kirsten B. Holven (ORCID: https://orcid.org/0000-0002-8674-9703)
- Geir Øystein Andersen (ORCID: https://orcid.org/0000-0003-1578-6440)
- Magnar Bjørås (ORCID: https://orcid.org/0000-0001-8759-1170)
- Lars Gullestad (ORCID: https://orcid.org/0000-0002-5932-6641)
- Kaspar Broch (ORCID: https://orcid.org/0000-0003-4316-805X)
- Bente Lise Halvorsen (ORCID: https://orcid.org/0000-0002-6529-6485)
- Ola Kleveland
- Ana Quiles‐Jiménez (ORCID: https://orcid.org/0000-0003-0090-589X)
- Anne Kristine Anstensrud (ORCID: https://orcid.org/0000-0003-1499-2402)
- Pål Aukrust (ORCID: https://orcid.org/0000-0002-6509-6221)
- Camilla Huse (ORCID: https://orcid.org/0000-0002-7694-5196)
- Kuan Yang (ORCID: https://orcid.org/0000-0002-2246-4864)
- Azita Rashidi
- Tuva Børresdatter Dahl (ORCID: https://orcid.org/0000-0001-7818-9411)
- Jonas Øgaard (ORCID: https://orcid.org/0000-0001-9194-5939)
- Vigdis Bjerkeli
Institutions
- Oslo University Hospital (NO)
- Brigham and Women's Hospital (US)
- University of Oslo (NO)
- Norwegian University of Science and Technology (NO)
- St Olav's University Hospital (NO)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1532325
- Citations
- 3
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Direktør Throne Holsts Fond For Ernæringsforskning
- Helse Sør-Øst RHF