METTL3-mediated m6A modification regulates D-galactose-induced skin fibroblast senescence through miR-208a-5p
These results establish an m6A-dependent METTL3/miR-208a-5p/OPA1 axis that regulates mitophagy and skin aging. Pharmacological rescue of mitophagy highlights this pathway's therapeutic relevance for age-related dermatopathology.
Authors
- Zhen Guo (ORCID: https://orcid.org/0000-0002-8421-4852)
- Meng Yi (ORCID: https://orcid.org/0000-0003-1315-5311)
- Mingde Liao
- Gaoxiang Huang
- Jiyong Tan
- Jing Li (ORCID: https://orcid.org/0000-0003-0218-8169)
- Jing Wang (ORCID: https://orcid.org/0009-0001-4936-6244)
- Sainan Sun
- Qing Yan
- Qi Wang (ORCID: https://orcid.org/0000-0002-1556-2167)
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- Central People's Hospital of Zhanjiang (CN)
- Guangxi University of Chinese Medicine (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1577783
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province
- Medical Science and Technology Foundation of Guangdong Province