Evolution of ceftazidime-avibactam resistance driven by variation in blaKPC-2 to blaKPC-190 during treatment of ST11-K64 hypervirulent Klebsiella pneumoniae
The KPC-190 variant underscores the adaptive evolution of <i>bla</i> <sub>KPC</sub> under antibiotic pressure, combining CZA resistance via enhanced ceftazidime affinity and avibactam evasion with retained carbapenem hydrolysis. Its association with hypervirulence plasmids and IS26-mediated mobility poses a dual threat for dissemination. These findings highlight the urgent need for genomic surveillance and alternative therapies (e.g., meropenem-vaborbactam) to address KPC-190-mediated resistance.
Authors
- Qiang Han (ORCID: https://orcid.org/0000-0002-0823-8553)
- Yan Geng (ORCID: https://orcid.org/0000-0001-8861-7686)
- Lingjuan Huang (ORCID: https://orcid.org/0000-0003-0222-3913)
- Zeshi Liu (ORCID: https://orcid.org/0009-0001-2251-2440)
- Yanping Zhang (ORCID: https://orcid.org/0000-0002-8847-8214)
- Lei Jing (ORCID: https://orcid.org/0000-0002-1181-2536)
- He Aili
- Jian Yin (ORCID: https://orcid.org/0000-0003-0498-8565)
- Ke Lei (ORCID: https://orcid.org/0000-0002-2523-5530)
- Xue Zhang (ORCID: https://orcid.org/0009-0001-9537-6363)
Institutions
- Xi'an Medical University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.3389/fcimb.2025.1607127
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- Xi'an Municipal Bureau of Science and Technology
- Xi'an Medical University