Exploring the shared molecular mechanisms of primary hypertension and IgA vasculitis through a case report and combining bioinformatics analysis
We found that aggressive BP-lowering agents were necessary for managing PHTN. This study also reveals the common pathogenesis underlying both PHTN and IgAV. Moving forward, these shared hub genes could serve as novel targets for more in-depth mechanistic investigations and the development of new therapeutic interventions for individuals affected by PHTN and IgAV.
Authors
- Jia‐Wu Feng (ORCID: https://orcid.org/0000-0003-3737-4850)
- Hong‐Xi Xu (ORCID: https://orcid.org/0000-0001-6238-4511)
- Qian Shen (ORCID: https://orcid.org/0000-0002-4621-4659)
- Qijiao Wei (ORCID: https://orcid.org/0000-0002-7791-0630)
- Yifei Mu (ORCID: https://orcid.org/0000-0002-7786-1189)
- Sun Li (ORCID: https://orcid.org/0000-0002-5695-3404)
- Haimei Liu (ORCID: https://orcid.org/0000-0002-0079-9444)
Institutions
- First People’s Hospital of Zunyi (CN)
- Children's Hospital of Fudan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1596174
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00