Hydroxysafflor yellow A alleviates oxidative stress and inflammatory damage in the livers of mice with nonalcoholic fatty liver disease and modulates gut microbiota
HSYA demonstrates potent anti-inflammatory and antioxidant effects, effectively mitigating liver inflammation and oxidative stress in NAFLD mice. Its therapeutic mechanisms may involve modulating gut microbiota and regulating serum phenylalanine and tyrosine metabolism, offering insights into its potential as a treatment for NAFLD.
Authors
- Asmaa Mohamed Mahmoud Ali (ORCID: https://orcid.org/0000-0002-7421-5085)
- Jiayuan He
- Xueyun Dong (ORCID: https://orcid.org/0009-0003-2724-9033)
- Pingping Wang (ORCID: https://orcid.org/0000-0001-8888-8005)
- Wen Sun (ORCID: https://orcid.org/0000-0002-5367-3861)
- Liang Wu (ORCID: https://orcid.org/0000-0002-8241-2433)
- Tan Jiajun
Institutions
- Jiangsu University (CN)
- Egyptian e-Learning University (EG)
- Taizhou Second People's Hospital (CN)
- Xinjiang Uygur Autonomous Region Disease Prevention and Control Center (CN)
- Affiliated Hospital of Jiangsu University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.3389/fphar.2025.1568608
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Government of Jiangsu Province