Understanding mechanisms of Polygonatum sibiricum-derived exosome-like nanoparticles against breast cancer through an integrated metabolomics and network pharmacology analysis
This was the first time that the PSELNs have been studied against cancer. It was verified that they have anti-BC activity, and the mechanism may be related to targets such as ESR1 and PPARG, regulated by active metabolites in the PSELNs. This work laid a foundation and reference for more follow-up related research studies.
Authors
- Shuya Zhang (ORCID: https://orcid.org/0000-0001-5785-884X)
- Lun Wu (ORCID: https://orcid.org/0000-0002-5663-2969)
- Zhihao Li (ORCID: https://orcid.org/0000-0002-5654-7043)
- Jingjian Liu (ORCID: https://orcid.org/0009-0000-0496-6273)
- Qinhua Chen (ORCID: https://orcid.org/0000-0002-9108-1314)
- Fangling Ren
- Yang Yang (ORCID: https://orcid.org/0000-0002-1163-2359)
- Jun Zhu (ORCID: https://orcid.org/0000-0002-0551-273X)
- Tingwen Ming
- Bing Shang
Institutions
- Hubei University of Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China National Pharmaceutical Group Corporation (China) (CN)
- Shenzhen Bao'an District People's Hospital (CN)
- Dongfeng General Hospital (CN)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2025-06-06
- DOI
- https://doi.org/10.3389/fchem.2025.1559758
- Citations
- 5
- Primary Topic
- Seaweed-derived Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 11.37
Funders
- Hubei Provincial Department of Education
- National Natural Science Foundation of China
- Sanming Project of Medicine in Shenzhen
- Science and Technology Planning Project of Shenzhen Municipality