Unraveling the role of GPCR signaling in metabolic reprogramming and immune microenvironment of lung adenocarcinoma: a multi-omics study with experimental validation
In summary, this study reveals the pivotal role of GPCR signaling particularly mediated by ADM in orchestrating metabolic reprogramming and immune modulation in LUAD. ADM emerges as a potential predictive biomarker and therapeutic target, offering valuable implications for optimizing strategies.
Authors
- Shilei Zhao (ORCID: https://orcid.org/0000-0002-3785-7732)
- Zhaoxuan Wang (ORCID: https://orcid.org/0000-0003-4954-4941)
- Cheng Wang (ORCID: https://orcid.org/0000-0003-3665-4965)
- Chundong Gu (ORCID: https://orcid.org/0000-0002-2981-6578)
Institutions
- Dalian Medical University (CN)
- Wuxi No.2 People's Hospital (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1606125
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94